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联系人: Nick Zagorski
nzagorski@asbmb.org
301-634-7366
美国生化与分子生物学会

着床前基因诊断可能引发罹患神经疾病的风险

着床前基因诊断 (PGD, Preimplantation genetic diagnosis)能帮助许多夫妇得到健康的胎儿,它一直被认为是一种安全的检测手段。但是,一项对PGD在小鼠中进行的长期分析表明,这种方法可能会提高成年阶段体重增加和记忆力下降的风险。

PGD是一种用于辅助生殖技术的检测,它是为了确保夫妇双方不会将遗传疾病(例如:德系犹太人中高发的Tay-Sachs氏症)的缺陷基因传递给他们的后代。尽管检测过程中包括对发育期胚胎的操作,但一般认为PGD不会引起任何严重的健康问题,目前尚没有对此进行过长期精确的研究。

Ran Huo、Qi Zhou及其同事们利用小鼠模型对卵裂球进行活检,模拟PGD过程中的手术操作,他们发现这样的检测会影响胎儿、新生儿及成人阶段的发育。

他们发现,进行活检的实验组和对照组相比,植入子宫前它们的胚胎发育没有差异,这与人类中发现的结果相同。但是,植入后,活检过的胚胎出生率远低于对照组。

研究者跟踪了小鼠出生后的生理学及行为学特性,在很多方面这两组小鼠的特征相似,但是活检组的小鼠平均体重更高而且在迷宫测试中表现的记忆力更差。为了进一步搞清该实验对记忆的影响,研究者对成年小鼠的大脑进行了蛋白质组分析,他们发现在活检组和对照组之间,有36种蛋白质有显著差异,其中17种和神经退行性疾病密切相关,如阿兹海默症和唐氏综合症。

该文作者认为,发育中的神经系统可能对卵裂球活检很敏感,为了保证PGD的安全性,还需要进行进一步的研究以确定PGD的长期影响。

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原文题目: “Evaluation of Blastomere Biopsy Using a Mouse Model Indicates the Potential High Risk of Neurodegenerative Disorders in the Offspring”

作者:Yang Yu, Jindao Wu, Yong Fan, Zhuo Lv, Xuejiang Guo, Chun Zhao, Rong Zhou, Zhuo Zhang, Fuqiang Wang, Min Xiao, Ling Chen, Hui Zhu, Wen Chen, Min Lin, Jiayin Liu, Zuomin Zhou, Liu Wang, Ran Huo, Qi Zhou and Jiahao Sha

原文连接: http://www.mcponline.org/cgi/content/full/8/7/1490
通讯作者:
Ran Huo, Laboratory of Reproductive Medicine, Nanjing Medical University, China; (currently on home leave) E-mail: huoran@njmu.edu.cn

Qi Zhou, State Key Laboratory of Reproductive Biology, Chinese Academy of Sciences, Beijing, China; Tel.: 86-10-64807299, E-mail: qzhou@ioz.ac.cn

The American Society for Biochemistry and Molecular Biology is a nonprofit scientific and educational organization with over 11,900 members in the United States and internationally. Most members teach and conduct research at colleges and universities. Others conduct research in various government laboratories, nonprofit research institutions and industry. The Society’s student members attend undergraduate or graduate institutions.

Founded in 1906, the Society is based in Bethesda, Maryland, on the campus of the Federation of American Societies for Experimental Biology. The Society’s purpose is to advance the science of biochemistry and molecular biology through publication of the Journal of Biological Chemistry, the Journal of Lipid Research, and Molecular and Cellular Proteomics, organization of scientific meetings, advocacy for funding of basic research and education, support of science education at all levels, and promoting the diversity of individuals entering the scientific work force.

For more information about ASBMB, see the Society’s Web site at www.asbmb.org.



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