[ Back to EurekAlert! ] Public release date: 4-Dec-2013
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Contact: Meng Zhao
Neural Regeneration Research

Baicalin inhibits neurotoxicity of colistin sulfate effectively

Pretreatment with baicalin (100 μg/mL) markedly decreased condensation and fragmentation of nuclei in colistin sulfate-treated PC12 cells.

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Baicalin, a type of flavonoid extracted from the dried root of Scutellaria baicalensis georgi, has been shown to effectively inhibit cell apoptosis. Colistin sulfate, a cyclic cationic polypeptide antibiotic, has been shown to have renal and neurological side effects. Dr. Hong Jiang and colleagues from Northeast Agricultural University assumed that baicalin would suppress colistin sulfate-induced neuronal apoptosis. In a study by Jiang et al, PC12 cells were pretreated with baicalin (25, 50 and 100 μg/mL), and exposed to 125 μg/mL colistin sulfate. Cell morphology markedly changed, and cell viability increased. Moreover, caspase-3 activity, lactate dehydrogenase level and free radical content decreased. Experimental results indicated that baicalin inhibited colistin sulfate-induced PC12 cell apoptosis by suppressing free radical injury, and reducing caspase-3 activity and lactate dehydrogenase activity. These findings are published in the Neural Regeneration Research (Vol. 8, No. 28, 2013).


Article: " Baicalin inhibits colistin sulfate-induced apoptosis of PC12 cells," by Hong Jiang1, 2, Pengfei Lv3, Jichang Li1, Hongjun Wang2, Tiezhong Zhou2, Yingzi Liu2, Wei Lin1 (1 Institute of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, Heilongjiang Province, China; 2 Institute of Animal Husbandry and Veterinary Medicine, Liaoning Medical University, Jinzhou 121001, Liaoning Province, China; 3 Scientific Research Department, Liaoning Medical University, Jinzhou 121001, Liaoning Province, China)

Jiang H, Lv PF, Li JC, Wang HJ, Zhou TZ, Liu YZ, Lin W. Baicalin inhibits colistin sulfate-induced apoptosis of PC12 cells. Neural Regen Res. 2013;8(28):2597-2604.

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